The Institute of Pharmacology and Toxicology of the University of Zurich is a world-leading institution in the field of neuropharmacology and general neurophysiology. It comprises apart from other neurophysiological techniques a strong multimodal imaging expertise, ranging from microscopy to magnetic resonance imaging. The Experimental Imaging and Neuroenergetics group headed by Professor Weber is one of five research groups affiliated with this institute. The Molecular Imaging Group is lead by Professor Rudin, who is a world-leader in his field.
Prof. Dr. Bruno Weber is Professor at the University of Zurich and Chair of Experimental Imaging. Bruno Weber’s group (Experimental Imaging and Neuroenergetics) investigates the mechanisms governing the regulation of blood flow and metabolism in brain tissue. Combining ex-vivo and in-vivo experiments in rodents they aim at closing the gap between structural and functional aspects of the hemodynamic response. Furthermore, they focus on the interaction of neurons and astrocytes in terms of energy metabolism. They use a wide range of imaging tools to interrogate neurometabolism. Above all, they are pioneering the use of genetically encoded energy substrate sensors for determining substrate concentrations at the single cell level in vivo.
Within GLINT, the group will provide measurements of energy substrate levels, particularly of glucose, in single cells in response of the injection of all glucose analogues relevant for this consortium. They will use in vivo two-photon imaging in combination with genetically encoded sensors to determine intracellular concentrations of energy substrates (glucose, lactate, pyruvate). This will be done in combination with preclinical MR protocols in rodents.